品系特点
原始参考文献
Info 当使用该小鼠品系发表文献时,请引用原始参考文献,并在材料方法中提供该品系的品系货号:JAX stock #380050
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品系详情
用高脂饲料饲喂的 C57BL/6J 小鼠,会出现肥胖症、轻度高血糖症、血脂异常和糖耐量减低(请参见表型数据详情)。
1984 年之前的某一时间,C57BL/6J 小鼠的烟酰胺核苷酸转移酶 (Nnt) 外显子 7-11 发生了自然缺失。这种缺失导致 NNT 蛋白的缺失,与葡萄糖内稳态控制受损和胰岛素分泌减少相关。此突变不存在于 C57BL/6JEi、C57BL/6N、C57BL/6NJ、C57BL/6ByJ、C57BL/10J、C57L/J 或 C58/J 小鼠中 (Toye AA, et al, Diabetologia, 2005)。因为品系 C57BL/6JEi 是在 1976 年从 C57BL/6J 中分离出来的,而Nnt 缺失发生在 1976 年至 1984 年之间。
品系建立
C57BL/6J 近交品系由 CC Little 博士将来自 Abbie Lathrop 女士的储备库中 57 号雌鼠与 52 号雄鼠交配繁育获得。这一交配繁育也产生了 C57L 和 C57BR 品系。
参考文献
精选参考文献

当使用该小鼠品系发表文献时,请引用原始参考文献,并在材料方法中提供该品系的品系货号:JAX stock #380050


2016

Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium.

Fontaine DA , et al.

PubMed:26696638

MGI:J:231066

Diabetes 65(1):25-33

2008

Genetic background determines metabolic phenotypes in the mouse.

Champy MF , et al.

PubMed:18392653

MGI:J:137669

Mamm Genome 19(5):318-31

2005

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.

Toye AA , et al.

PubMed:15729571

MGI:J:106692

Diabetologia 48(4):675-86

2004

Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.

Petkov PM , et al.

PubMed:15081119
MGI:J:89298
Genomics 83(5):902-11
2002

Initial sequencing and comparative analysis of the mouse genome.

Waterston RH , et al.

PubMed:12466850
MGI:J:80507
Nature 420(6915):520-62
2001

Genetic loci determining bone density in mice with diet-induced atherosclerosis.

Drake TA , et al.

PubMed:11328966
MGI:J:69682
Physiol Genomics 5(4):205-15
1998

Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice.

Black BL , et al.

PubMed:9826212
MGI:J:50965
Metabolism 47(11):1354-9
1995

Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes.

Kirk EA , et al.

PubMed:7595076
MGI:J:28648
J Lipid Res 36(7):1522-32
1995

Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse.

Paigen B , et al.

PubMed:7625360
MGI:J:28248
Am J Clin Nutr 62(2):458S-462S
1994

Diet-induced obesity and diabetes in C57BL/6J and C57BL/KsJ mice

Surwit RS , et al.

PubMed:
MGI:J:40713
Mouse Genome 92:523-8
1991

Effects of atherogenic diet consumption on lipoproteins in mouse strains C57BL/6 and C3H.

Ishida BY , et al.

PubMed:1856605
MGI:J:109926
J Lipid Res 32(4):559-68
1990

Synthetic low and high fat diets for the study of atherosclerosis in the mouse.

Nishina PM , et al.

PubMed:2380634
MGI:J:27046
J Lipid Res 31(5):859-69
1985

Variation in susceptibility to atherosclerosis among inbred strains of mice.

Paigen B , et al.

PubMed:3841001
MGI:J:109950
Atherosclerosis 57(1):65-73
其它参考文献
2016

Unstable FoxP3+ T regulatory cells in NZW mice.

Depis F , et al.

PubMed:26768846
MGI:J:227903
Proc Natl Acad Sci U S A 113(5):1345-50
2014

RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration.

Ishimura R , et al.

PubMed:25061210
MGI:J:211326
Science 345(6195):455-9
2013

C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response.

Kumar V , et al.

PubMed:24357318
MGI:J:203183
Science 342(6165):1508-12
2011

Genetic polymorphisms among C57BL/6 mouse inbred strains.

Zurita E , et al.

PubMed:20506040
MGI:J:160203
Transgenic Res 20(3):481-9
2009

Genetic differences among C57BL/6 substrains.

Mekada K , et al.

PubMed:19448337
MGI:J:160204
Exp Anim 58(2):141-94
2009

Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen.

Zhu W , et al.

PubMed:19224206
MGI:J:146790
Immunogenetics 61(3):199-207
2008

Oxidative damage-induced inflammation initiates age-related macular degeneration.

Hollyfield JG , et al.

PubMed:18223656
MGI:J:129432
Nat Med 14(2):194-8
2007

Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains.

Moy SS , et al.

PubMed:16971002
MGI:J:138682
Behav Brain Res 176(1):4-20
2006

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice.

Freeman HC , et al.

PubMed:16804088
MGI:J:109356
Diabetes 55(7):2153-6
2004

Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.

Goren HJ , et al.

PubMed:15044376
MGI:J:90745
Endocrinology 145(7):3307-23
2004

An efficient SNP system for mouse genome scanning and elucidating strain relationships.

Petkov PM , et al.

PubMed:15342563
MGI:J:151913
Genome Res 14(9):1806-11
2003

Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity.

Rossmeisl M , et al.

PubMed:12882911
MGI:J:86027
Diabetes 52(8):1958-66
2003

Allergen-induced airway disease is mouse strain dependent.

Whitehead GS , et al.

PubMed:12626335
MGI:J:84265
Am J Physiol Lung Cell Mol Physiol 285(1):L32-42
2003

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.

Xu H , et al.

PubMed:14679177
MGI:J:86952
J Clin Invest 112(12):1821-30
2000

Genetic regulation of primitive hematopoietic stem cell senescence.

Chen J , et al.

PubMed:10781902
MGI:J:61814
Exp Hematol 28(4):442-50
2000

Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.

Ewart SL , et al.

PubMed:11017920
MGI:J:66641
Am J Respir Cell Mol Biol 23(4):537-45
2000

Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice.

Nguyen PV , et al.

PubMed:11067991
MGI:J:71278
J Neurophysiol 84(5):2484-93
2000

Genetic heterogeneity of angiogenesis in mice.

Rohan RM , et al.

PubMed:10783140
MGI:J:61808
FASEB J 14(7):871-6
2000

The Dalila effect: C57BL6 mice barber whiskers by plucking.

Sarna JR , et al.

PubMed:10680755
MGI:J:71538
Behav Brain Res 108(1):39-45
2000

Macronutrient diet selection in thirteen mouse strains.

Smith BK , et al.

PubMed:10749765
MGI:J:61602
Am J Physiol Regul Integr Comp Physiol 278(4):R797-805
1999

Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice.

Beamer WG , et al.

PubMed:10556421
MGI:J:58152
Mamm Genome 10(11):1043-9
1998

Comparison of acute endotoxin-induced lesions in A/J and C57BL/6J mice.

O'Malley J , et al..

PubMed:9864862
MGI:J:51631
J Hered 89(6):525-30
1998

Reversal of diet-induced obesity and diabetes in C57BL/6J mice.

Parekh PI , et al.

PubMed:9751238
MGI:J:49858
Metabolism 47(9):1089-96
1998

Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11.

Roberts JE , et al.

PubMed:9720874
MGI:J:49726
Mol Microbiol 29(2):581-91
1997

Distortion product otoacoustic emissions in the C57BL/6J mouse model of age-related hearing loss.

Parham K , et al.

PubMed:9367243
MGI:J:44149
Hear Res 112(1-2):216-34
1996

Genetic variability in adult bone density among inbred strains of mice.

Beamer WG , et al.

PubMed:8739896
MGI:J:33789
Bone 18(5):397-403
1996

Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss.

Erway LC , et al.

PubMed:8735078
MGI:J:33970
Hear Res 93(1-2):181-7
1995

Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.

Surwit RS , et al.

PubMed:7752914
MGI:J:25120
Metabolism 44(5):645-651
1994

Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts.

Bultman SJ , et al.

PubMed:8125260
MGI:J:16984
Genes Dev 8(4):481-90
1994

Alcohol consumption by C57BL/6, BALB/c, and DBA/2 mice in a limited access paradigm.

Le AD , et al.

PubMed:8146231
MGI:J:17161
Pharmacol Biochem Behav 47(2):375-8
1994

Microphthalmia and associated abnormalities in inbred black mice.

Smith RS , et al.

PubMed:7898027
MGI:J:24131
Lab Anim Sci 44(6):551-60
1994

Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene.

Vrieling H , et al.

PubMed:8202545
MGI:J:18750
Proc Natl Acad Sci U S A 91(12):5667-71
1993

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.

Miller MW , et al.

PubMed:8449404
MGI:J:4186
Genes Dev 7(3):454-67
1993

Atherosclerosis and plasma and liver lipids in nine inbred strains of mice.

Nishina PM , et al.

PubMed:8355588
MGI:J:13267
Lipids 28(7):599-605
1992

Molecular characterization of the mouse agouti locus.

Bultman SJ , et al.

PubMed:1473152
MGI:J:3523
Cell 71(7):1195-204
1992

Dietary obesity in nine inbred mouse strains.

West DB , et al.

PubMed:1621856
MGI:J:1348
Am J Physiol 262(6 Pt 2):R1025-32
1990

Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors.

Jiao S , et al.

PubMed:1971301
MGI:J:15484
J Lipid Res 31(3):467-77
1990

Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.

Paigen B , et al.

PubMed:2317166
MGI:J:22615
Arteriosclerosis 10(2):316-23
1986

Differences in susceptibility of inbred mice to Bacillus anthracis.

Welkos SL , et al.

PubMed:3081444
MGI:J:8197
Infect Immun 51(3):795-800
1982

Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes.

Schlagel CJ , et al.

PubMed:6980940
MGI:J:6835
J Immunol 129(4):1530-3
等位基因参考文献



















基因分型和繁育
此品系繁育表现良好。
繁育策略
同胞兄弟姐妹交配
外观
被毛颜色
详情

 

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Related Genotype: a/a

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380050
B6 DIO
肥胖症,代谢性疾病,炎症性疾病